Sarcoidosis is an inflammatory multisystem granulomatous disease of unknown etiology.

Sarcoidosis frequently manifests initially as an ocular problem. It is a granulomatous panuveitis with retinal vasculitis, vascular sheathing, periphlebitis, vitreous snowballs or string of pearls, yellow-white retinal/choroidal granulomas, anterior chamber cells and flare, mutton fat keratic precipitates, Koeppe/Busacca iris nodules, and macular edema.

Anterior uveitis is the most common ocular manifestation of sarcoidosis, affecting 25% of patients with the disorder.

Systemic findings include hilar adenopathy, pulmonary fibrosis, pulmonary parenchymal involvement, erythema nodosum, subcutaneous nodules, and lymphadenopathy.